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Current operating lease liabilities Operating lease liability, current portion Operating Lease, Liability, Current Laboratory equipment. Laboratory Equipment [Member] Laboratory Equipment Accumulated Deficit Retained Earnings [Member] Over-Allotment Option [Member] Overallotment Option Payments to Acquire Property, Plant, and Equipment, Total Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Accrued Liabilities, Current [Abstract] Document Transition Report Document Transition Report Kyowa Kirin Collaboration and License Agreement [Abstract] Kyowa kirin collaboration and license agreement. Current contract liabilities Contract liability current Contract liability current. Furniture and fixtures 1. Furniture And Fixtures1 [Member] Furniture and Fixtures Cash equivalents and Short-term investments, Amortized Cost Cash Equivalents And Short Term Investments Amortized Cost Cash equivalents and short term investments amortized cost. Lessee, Operating Lease, Liability, to be Paid, Year Two 2027 Proceeds from Stock Plans Proceeds from issuance of stock under employee stock purchase plan Proceeds from issuance of stock under equity plans Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Minimum [Member] Minimum Common Stock [Member] Common Stock Additional Paid- In Capital Additional Paid-in Capital [Member] Debt Securities, Available-for-sale, Current, Total Short-term investments Debt Securities, Available-for-Sale, Current Short-term investments, Estimated Fair Value Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Other Comprehensive Income (Loss), Net of Tax [Abstract] Other comprehensive income: Income Statement Location Statement of Income Location, Balance [Domain] Royalty recognized Royalty recognized Royalties recognized Lessee, Operating Lease, Liability, to be Paid, Year One 2026 Other Assets, Noncurrent, Total Other long-term assets Other Assets, Noncurrent Kyowa Agreement Kyowa Agreement [Member] Kyowa agreement. Proceeds from Maturities, Prepayments and Calls of Short-Term Investments Maturities of short-term investments Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Debt Securities, Available-for-sale, Allowance for Credit Loss, Ending Balance Debt Securities, Available-for-sale, Allowance for Credit Loss, Beginning Balance Debt Securities, Available-for-sale, Allowance for Credit Loss, Total Allowance for credit losses Debt Securities, Available-for-Sale, Allowance for Credit Loss Segment Reporting, Expense Information Used by CODM, Description Segment reporting, expense information used by CODM, description Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Common Stock, Value, Issued Common stock, $0.0001 par value; 200,000 shares authorized; 66,838 and 66,572 shares issued and outstanding as of June 30, 2022 and December 31, 2021, respectively Common stock, $0.0001 par value; 200,000 shares authorized; 80,778 and 78,229 shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Schedule Of Fair Value Measurements, By Major Security Type Fair Value, Assets Measured on Recurring Basis [Table Text Block] Operating Lease, Liability, Total Operating Lease Liability Total operating lease liabilities Operating lease liabilities Investments Measured at Fair Value on Recurring Basis Debt Securities, Available-for-Sale [Table Text Block] Measurement Frequency [Axis] Measurement Frequency Lessee Operating Lease Liability Tenant Improvement Allowance Reimbursements Yet To Be Received Lessee operating lease liability tenant improvement allowance reimbursements yet to be received. Less: tenant improvement allowance reimbursements yet to be received Less: tenant improvement allowance reimbursements yet to be received Weighted Average Number of Shares Outstanding, Diluted, Total Weighted Average Number of Shares Outstanding, Diluted Weighted average number of shares used in computing net loss per share, diluted Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Schedule of Segment Reporting Information, by Segment [Table Text Block] Summary of Segment Profit or Loss, Including Significant Expenses Accounts Receivable, after Allowance for Credit Loss, Current Accounts Receivable, after Allowance for Credit Loss, Current, Total Receivable from contracts with collaborators Lease agreement additional extended lease term Lessee, Operating Lease, Renewal Term Total lease payments Lessee, Operating Lease, Liability, to be Paid Development Services for Monotherapy [Member] Development services for monotherapy. Development Services for Monotherapy Number of leases that include renewal option. Number of leases that include renewal option Available For Sale Securities Debt Maturities One To Three Years Available for sale securities debt maturities one to three years. Short-term investments with maturities between one and two years Entity Small Business Entity Small Business Segment Reporting Information [Line Items] Entity Bankruptcy Proceedings, Reporting Current Issuance of Pre-funded Warrants to Purchase Common Stock Net of Offering Costs Issuance of pre-funded warrants to purchase common stock, net of offering costs Issuance of pre-funded warrants to purchase common stock, net of offering costs. U.S. Treasury Securities US Treasury Securities [Member] Credit Facility Credit Facility [Axis] San diego corporate headquarters lease. San Diego corporate headquarters lease [member] San Diego Corporate Headquarters Lease Transaction price Collaborative Arrangement Transaction Price Collaborative arrangement transaction price. Accretion (Amortization) of Discounts and Premiums, Investments Amortization of premium and accretion of discounts on short-term investments, net Financing Activities Net Cash Provided by (Used in) Financing Activities [Abstract] Number of available-for-sale securities Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions Asset Class Asset Class [Axis] Short-term investments maturities, description Short Term Investments Maturities Description Short term investments maturities description. Contract liability Contract liability. Contract liability Revenue from Contract with Customer, Product and Service [Extensible Enumeration] Sales based milestones recognized Sales based milestones recognized. Sales based milestones recognized ROU assets obtained in exchange for operating lease liabilities Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Measurement Frequency Measurement Frequency [Domain] Level 3 Fair Value, Inputs, Level 3 [Member] Weighted-average remaining lease term Operating Lease, Weighted Average Remaining Lease Term Subsequent Events Subsequent Events [Text Block] Public offering prefunded warrants. Public Offering Prefunded Warrant [Member] Public Offering Prefunded Warrants Accounts Payable, Current Accounts Payable, Current, Total Accounts payable Accounts Payable and Accrued Liabilities, Current Accounts payable and accrued expenses Total accounts payable and accrued expenses Collaboration Revenue [Member] Collaboration Revenue.