Kura Oncology Reports Preclinical Data Supporting Use of Tipifarnib to Prevent Emergence of Resistance to Osimertinib in Non-Small Cell Lung Cancer
– Late-breaking presentation at AACR demonstrates potential to significantly delay onset of drug resistance to EGFR-targeted therapies through combination with a farnesyl transferase inhibitor –
– Company to initiate clinical trial of tipifarnib in combination with osimertinib in NSCLC in the third quarter of 2022 –
– IND for KO-2806, a next-generation farnesyl transferase inhibitor, remains on track for submission in the fourth quarter of 2022 –
The new findings, generated through a collaboration with
Using Rho-pathway inhibitor screening, researchers at
“These preclinical data, combined with our own translational research, support the potential use of tipifarnib in combination with osimertinib to effectively and durably prevent relapse to EGFR-targeted therapies,” said
Kura is preparing to initiate a Phase I clinical trial (KURRENT-LUNG) of tipifarnib in combination with osimertinib in treatment-naïve locally advanced/metastatic EGFR mutated NSCLC and expects to dose the first patient in the third quarter of 2022. The Company intends to perform initial clinical evaluation with tipifarnib while in parallel advancing KO-2806, the lead development candidate in its next-generation FTI program, through investigational new drug (IND)-enabling studies. Kura plans to submit an IND application for KO-2806 in the fourth quarter of 2022.
This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, the potential use of tipifarnib in combination with osimertinib to effectively and durably prevent relapse to EGFR-targeted therapies, the timing of activities with respect to the clinical trial of tipifarnib in combination with osimertinib in NSCLC, and the timing of submission of an IND application for KO-2806. Factors that may cause actual results to differ materially include the risk that compounds that appeared promising in early research or clinical trials do not demonstrate safety and/or efficacy in later preclinical studies or clinical trials, the risk that Kura may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings, applications and other interactions with regulatory bodies, risks associated with reliance on third parties to successfully conduct clinical trials, the risks associated with reliance on outside financing to meet capital requirements, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words “may,” “will,” “would,” “could,” “should,” “believes,” “estimates,” “projects,” “promise,” “potential,” “expects,” “plans,” “anticipates,” “intends,” “continues,” “designed,” “goal,” or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties the Company faces, please refer to the Company's periodic and other filings with the
Senior Vice President, Investor Relations &
Source: Kura Oncology, Inc.